Replicative Studies
نویسندگان
چکیده
منابع مشابه
Enabling Replicative Immortality
Molecular aspects of cancer continue to be uncovered by researchers around the world. Theses aspects will need to be exploited in the next generation of cancer treatments. Specific tumor suppressor genes such as p53 can serve as novel therapeutic targets as well. Although the scientific understanding of the actual steps in tumorigenesis is rather muddled, the differences between cancer and norm...
متن کاملG2E3 attenuating replicative stress
cells generally display an increased level of replicative stress. While in S phase, their replication forks undergo temporary stalling and sometimes even permanent collapse, leading to the accumulation of single stranded DNA and a DNA damage response. Strategies to exploit this phenomenon by further increasing replicative stress include the use of conventional DNA-damaging chemotherapeutics, bu...
متن کاملTherapeutic targeting of replicative immortality
One of the hallmarks of malignant cell populations is the ability to undergo continuous proliferation. This property allows clonal lineages to acquire sequential aberrations that can fuel increasingly autonomous growth, invasiveness, and therapeutic resistance. Innate cellular mechanisms have evolved to regulate replicative potential as a hedge against malignant progression. When activated in t...
متن کاملMicroarray analysis of replicative senescence
BACKGROUND Limited replicative capacity is a defining characteristic of most normal human cells and culminates in senescence, an arrested state in which cells remain viable but display an altered pattern of gene and protein expression. To survey widely the alterations in gene expression, we have developed a DNA microarray analysis system that contains genes previously reported to be involved in...
متن کاملVacuolar dynamics and replicative aging
DnA damage and genomic instability are central both to the evolution and treatment of cancer. As a result, in recent years, much interest has focused on cellular DnA damage responses and whether these can be manipulated for therapy. 1 DnA damage activates a complex, interacting web of DnA repair and cell cycle checkpoint processes that offer a diverse range of potentially druggable targets. 1 T...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Clinical Nursing Research
سال: 1993
ISSN: 1054-7738,1552-3799
DOI: 10.1177/105477389300200301